Neurodegenerative Diseases

Neurodegenerative diseases are incurable and debilitating conditions that result in progressive degeneration and / or death of nerve cells. This causes problems with movement (called ataxias), or mental functioning (called dementias). It is an umbrella term for a range of conditions which primarily affect the neurons in the human brain. The risk of being affected by a neurodegenerative disease increases dramatically with age. Population-wide health improvements have increased lifespan which, along with a larger generation of aging Americans, means more people may be affected by neurodegenerative diseases in coming decades. Sandhoff disease is a rare inherited disorder that progressively destroys nerve cells (neurons) in the brain and spinal cord. The most common and severe form of Sandhoff disease becomes apparent in infancy. Infants with this disorder typically appear normal until the age of 3 to 6 months, when their development slows and muscles used for movement weaken. Affected infants lose motor skills such as turning over, sitting, and crawling. 

This creates a critical need to improve our understanding of what causes neurodegenerative diseases and develop new approaches for treatment and prevention

 

  • Alzheimer’s Disease
  • Huntington’s Disease
  • Motor Neurone Diseases (MND)
  • Spinocerebellar Ataxia (SCA)
  • Spinal Muscular Atrophy (SMA)
  • Sandhoff Disease

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