Cancer Epigenetics

Cancer is caused by the failure of checks and balances that control cell numbers in response to the needs of the whole organism. The inappropriate function of genes that promote or inhibit cell growth or survival can be caused by errors introduced into the genetic code itself or by faulty epigenetic mechanisms deciding which genes can and cannot be expressed. Two of the main methods are DNA methylation and histone modification. Methylation involves tacking a methyl group onto DNA. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immunosurveillance.

                                

  • Cervical Cancer
  • Rhabdoid Tumor
  • Prostate Cancer
  • Brest Cancer
  • Chromatin dysregulation

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