Histone modifications

There are many types of histone modifications, including acetylation, methylation, ubiquitination, citrullination and phosphorylation of specific amino acids within the histone protein, usually towards the C-terminal ('tail') end of the protein.

Histone alterations control gene expression in two ways: by changing the general structure of chromatin and/or by regulating the binding of transcription effector molecules. Histone alterations control gene expression in two ways: by changing the general structure of chromatin and/or by regulating the binding of transcription effector molecules.



 


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