Molecular Diagnostics of Human Diseases

Several advances in machine learning has led to analysis of high-dimensional and multimodal biomedical data that have promised improvement in the detection, diagnosis, and therapeutic monitoring of early disease progression. Diagnostic tests and plasma analyte analysis do not determine nuclear-mitochondria defects with discoveries in clinical eipgenetics that identify the gene Sirtuin 1 to be defective and to be involved in toxic immune reactions relevant to mitophagy. Proteome blood analysis is now an important diagnostic procedure in medicine with existing proteomic biomarkers correlated with early disease progression in health and disease. Sirtuin 1 analysis in plasma and body fluids is essential to determine the importance of diagnostic clinical biochemisty tests and will allow early diagnosis of disease progression that involves cardiovascular disease, non-alcoholic fatty liver disease, metabolic disease and neurodegenerative diseases. Physicians have raised concerns for the prevalence of under diagnosis of various chronic diseases associated with the acceleration of programmed cell death in global diabetes and organ disease.


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