Epigenetic of neurological disease

Epigenetic mechanisms such as DNA methylation and modifications to histone proteins regulate high-order DNA structure and gene expression. Aberrant epigenetic mechanisms are involved in the development of many diseases, including cancer.

Both patients and healthcare costs are burdened by neurological disorders, particularly neurodegenerative disorders. Despite substantial research, therapy choices for people with these disorders are limited and, in most cases, only give minor symptomatic improvement. Aberrant epigenetic post-translational modifications of proteins are emerging as important elements in the pathogenesis of neurological disease.



 


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