Epigenetic of cancer


Global DNA hypomethylation and gene-specific hypermethylation have been observed in human cancer cells obtained from clinical tissue biopsies. During initial studies of cancer epigenetics, the genome of patients with colorectal cancer was reported to be hypomethylated. In these patients, regions that are hypermethylated under normal conditions and silent regions of the genome were found to be demethylated. In some malignancies, however, abnormal gene activity, such as inhibition of tumor-suppressor genes, has been linked to hypermethylation of CpG islands. By hypermethylating DNA, repeating DNA sequences such as microsatellites become functionally abnormal and cause tumorigenesis. microsatellites in colorectal and ovarian cancers are distorted by abnormal epigenetic modulations in the MLH1 promoter (a DNA repair gene).



Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence, but instead involve a change in the way the genetic code is expressed.



 


    Related Conference of Epigenetic of cancer

    November 29-30, 2021

    3rd International Conference on Neuroimaging and Neuroradiology

    Singapore, Singapore
    December 07-08, 2021

    2nd World Congres on Healthcare & Life-Science Research

    Bangkok, Thailand
    June 13-14, 2022

    4th World Congress on Complementary & Alternative Medicine

    Prague, Czech Republic

    Epigenetic of cancer Conference Speakers

    Recommended Sessions

    Related Journals

    Are you interested in