Epigenetics in Cardiovascular Disease

The DNA methylation, post-translational histone modifications, and microRNA regulation are key mechanisms underlying healthy cardiovascular function as well as heart disease and its precursors. There is increasing evidence for the involvement of epigenetics in human diseases such as cancer, inflammatory disease, and CV disease. Other chronic diseases are also susceptible to epigenetic modification such as metabolic diseases including obesity, metabolic syndrome, and diabetes mellitus. There is much evidence for the modification of epigenetics by nutrition and exercise. Epigenetics is also involved in cardiovascular risk factors such as smoking, diabetes, and hypertension. Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored

 

  • Cardiomyopathy
  • Hypertensive Heart Disease
  • Congenital Heart Disease
  • Pulmonary Heart Disease
  • Heart failure

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