Day 2 :
Keynote Forum
Aaron Han
American Hospital and Mohammed Bin Rashid Medical University, UAE
Keynote: Insight into antibiotic resistance and patterns of carbapenam-resistant Enterobacteriacea in the United Arab Emirates
Time : 9:00-10:00
Biography:
Aaron Han has completed MD/PhD program from Baylor College of Medicine with a thesis in Immunogenetics. He is a practicing Pathologist with interest in tumor pathology and special expertise in breast, gynecologic and hematolymphoid tumors. He also is a board certified Clinical Informaticist.
Abstract:
Keynote Forum
Jalil Hariri
Southern Jutland Hospital, Denmark
Keynote: Cervical cancer screening: Yesterday, today and tomorrow
Time : 10:00-10:45
Biography:
Jalil Hariri is a Consultant Pathologist at Southern Jutland Hospital as well as SLB Hospital in Denmark. He has published several papers and oral presentations addressing primarily non-gynecological liquid-based cytology, immunocytochemistry and HPV.
Abstract:
Cervical cancer is the only malignancy with a well-defined, detectable and treatable precursor which can make the disease preventable. The Pap-test screening was the start-shot for the secondary prophylaxis of cervical cancer and has regardless the subjectivity in morphological evaluation and the inevitable false negative rate, contributed to the decline in the incidence and the mortality of lesion during the last five decades. Lack of well-organized screenings programs and low socio-economic conditions diminished, meanwhile, the efficiency of the screening in developing countries, which necessitated tailored screening-programs for these areas. The discovery of HPV’s role in developing cervical cancer in the 1980s added the molecular biology test for HPV to the screenings program, initially as a triage test for mild cellular changes and since as primary Human Papillomavirus (HPV) screening. Primary prophylaxis was then launched by the HPV vaccination a decade ago. Specimen sampling for cytology was also improved by adding the cotton swab to Ayers spatula in the late 1970s/ early 1980s, which again was replaced by the Cytobrush a decade later. Yesterday’s irrigation smear by using the cytopipette and the micropipette during 1960s, was the forerunner for today’s liquid-based cytology. Fully or semi-automated imaging systems that are widely used today, were also preceded by several attempts for screening’s automation in 1960s. But cervical cancer, despite improvements of primary and secondary prophylactic measures, despite quality improvements of specimen sampling and specimen processing and despite improvements of the quality of microscopy is not eradicated yet. Can we do it tomorrow?
Keynote Forum
Massoud Houshmand
National Institute for Genetic Engineering and Biotechnology, Iran
Keynote: Genetic diagnostic methods
Time : 10:45-11:30
Biography:
Massoud Houshmand has completed his Ph.D. in Medical Molecular Genetic from Gothenburg University, Gothenburg, Sweden. He is the Head of the Genetic Diagnostic Laboratory, Faculty Member of National Institute for Genetic Engineering and Biotechnology and Responsible Director of Personalized Medicine journal. He has organized about 22 workshops and seminars and has published more than 220 papers and 17 books. He is the Winner of Best Iranian Researcher in Medical Genetic 2010, Winner of ISESCO prizes in Science & Technology 2014 and winner of Best Iranian Researcher 2015.
Abstract:
- Sessions: Molecular Pathology | Genomes and Epigenomes | Plant & Veterinary Pathology & Infections | Epigenetic Diseases and Clinical Applications | Anatomical Pathology | Gastrointestinal Pathology & Infections | Hematopathology | Epidemiology | Epigenetics and Biomarker | Biochemistry and Molecular Biology
Chair
Aaron Han
American Hospital and Mohammed Bin Rashid Medical University, UAE
Session Introduction
Jaber Haj-Ali
Charite University of Medicine, Germany and Consulting Medical Lab, Palestine
Title: Effect of low altitude on complete blood count parameters
Biography:
Jaber Haj-Ali has completed his Master’s degree from AL-Quds University and currently pursuing his PhD on telomere length measurements and pollution exposure at Charite University School of Medicine, Germany. He is the Founder and Director of consulting medical laboratory in Palestine.
Abstract:
Royce P Vincent
King’s College Hospital NHS Foundation Trust, UK
Title: Effect of metabolic surgery on non-alcoholic fatty liver disease
Biography:
Royce P Vincent is a Consultant Chemical Pathologist at King’s College Hospital NHS Foundation Trust and an Honorary Senior Lecturer at King’s College London, UK. He has a special interest in nutrition and endocrinology and is the Clinical Lead for Biochemistry and Parenteral Nutrition Services. He has obtained his MD (Res) at Imperial College London and his research interests are in obesity, endocrinology and clinical nutrition. He has published multiple original and review articles and is serving as an international Editorial Board Member for Translational Metabolic Syndrome Research
Abstract:
Non-Alcoholic Fatty Liver Disease (NAFLD) has become increasingly common worldwide over the last decades due to the obesity epidemic. By definition NAFLD requires that there is evidence of hepatic steatosis, either by imaging/histology or there are no causes for secondary hepatic fat accumulation-significant alcohol consumption, steatogenic medication, hereditary disorders etc. and is characterized by liver steatosis (accumulation of triglycerides >5% in liver weight). NAFLD is strongly associated with metabolic syndrome (insulin resistance, obesity and dyslipidemia). The disease reaches a peak in the fifth and sixth decades of life and at present nearly 25% of adults in Europe with fatty liver have NAFLD. NAFLD is a clinic-pathological entity that comprises a liver disease spectrum spanning from non-inflammatory isolated steatosis to NonAlcoholic Steatohepatitis (NASH), a more aggressive form of the disease, which is characterized by steatosis, inflammatory changes and varying degrees of liver fibrosis to end-stage liver disease. Furthermore, NAFLD may be complicated by cirrhosis or Hepatocellular Carcinoma (HCC). It is now set to become the major cause of liver transplantation in adults as it is the most important cause of cryptogenic cirrhosis. The pathogenesis of NAFLD is multifactorial but is yet to be fully elucidated. This session will explore our current knowledge about the pathophysiology of obesity associated liver disease, its management strategies and the role of metabolic surgery to address this global health problem.
Adam Elzagheid
University of Benghazi & Biotechnology Research Centre, Libya
Title: Survivin and livin expression as prognostic markers in the primary breast cancer and their lymph node metastases
Biography:
Adam Elzagheid is a Professor at Biocenology Research Centre (BTRC), acting as a General Director of BTRC, Tripoli, Libya. He has worked as a Dean of Faulty of Medicine, Benghazi University, Benghazi, Libya, Head of Department of Pathology, Faculty of Medicine, University of Benghazi. Post-doctoral Fellow and Research Associate at University of Turku, Faculty of Medicine, Oncology and Pathology Departments, Turku, Finland.
Abstract:
Aim: To assess the prognostic significant of survivin and livin protein expression in primary invasive breast cancer and in metastatic breast cancer to lymph node.
Material & Methods: The present study consists of archival samples from 78 patients of invasive breast cancer during 20102014 diagnosed at Misurata Cancer Center, Misurata, Libya. Tumor biopsies were analyzed for expression of survivin and livin by immunohistochemical, different grading systems were tested for survivin and livin expression.
Results: Survivin expression in primary breast cancer shows a significant correlation between survivin expression and site of tumor (P=0.021), higher expression of survivin was in patients without recurrence (p=0.036), survivin expression correlated significantly with unifocal tumor (P=0.001), Moreover HER-2 negative tumor express survivin more than HER-2 positive tumor (P=0.047). There was no significant difference in survivin expression as regards histological grade, histological type, lymph node status, tumor stage, TNM classification, estrogen, progesterone receptors, distance metastases, chemotherapy, radiotherapy, hormone replacement, vascular invasion, surgical margin, positive family history. Livin expression in primary breast cancer shows a significant correlation (P=0.025) with positive family history. There was no significant association with other clinicopathological parameters. We further studied the association of survivin and livin expression with secondary breast cancer (lymph node metastases), we found that primary tumor show higher survivin expression (82%) compared with secondary breast cancer (34%) while livin expression did not differ between the primary (71%) and secondary breast cancer (84%).
Conclusion: Survivin expression in primary breast cancer is significantly associated with parameters of good prognosis. Livin expression in primary breast cancer is significantly associated with positive family history of breast cancer.
Hamid Reza Edraki
Shahid Beheshti University of Medical Sciences and Health Sciences, Iran
Title: Fetal MRI in congenital phocomelia
Biography:
Abstract:
Applying MRI during pregnancy to detect fetus abnormalities. In this case the child is afflicted by phocomelia. A male fetus is detected in 32 week of gestational age by Trans abdominal sonography, right unilateral phocomelia is diagnosed for this patient. Right shoulder, arm and elbow are seen developed but just only proximal epiphysis of radius and ulna are seen. The rest of forearm bones and hand are not developed. The mother has not taken thalidomide or the other pills during pregnancy. After delivery, radiography was performed for newborn and this type of phocomelia was approved. Autosomal recessive genetic disorder is represented for this patient after sonography 2D and 3D. Fetal MRI was also performed and then phocomelia was detected after delivery. Pathology of the newborn, confirmed the phocomelia of right upper extremity. Radiography of right arm, elbow and forearm was done and epiphysis nuclei of proximal, of radial and ulnar bones. Hand surgeon visited him and planned for cleavage of soft tissue of right elbow for fork appearance functional forearm in 3 month later.
Termeh Ghorbanian Bolouri
Islamic Azad University, Iran
Title: A spectroscopic report on the ingestion of carbonic anhydrase onto the nanoporous silica nanoparticle
Biography:
Abstract:
Herein, KIT-6 nanoporous silica nanoparticles were used as a solid support for immobilization of bovine carbonic anhydrase, isoform II (BCA II). The zeta potential study revealed that KIT-6 and BCA II provided negative (-13.58±1.95 mV) and positive (4.23±0.72 mV) charge distribution, respectively. Dynamic Light Scattering (DLS) analysis also showed that the hydrodynamic radius of KIT-6 is less than 100 nm. In addition, the structural studies of free and immobilized BCA II against urea-induced denaturation were investigated by Circular Dichroism (CD) and fluorescence spectroscopy. CD studies showed that the absorbed BCA II, in comparison with the free enzyme, demonstrated higher stability against rising urea concentration. Fluorescence spectroscopy showed lower values of Stern-Volmer constant (KSV) for immobilized BCA II relative to free enzyme, reflecting the relative enzyme stability of BCA II after immobilization. Melting temperature (Tm) measurement of free and immobilized BCA II showed that immobilized enzyme had a more stable structure (Tm=71.9 ºC) relative to the free counterpart (Tm= 64.7 ºC). In addition, the immobilized BCA II showed pronounced stabilities against pH and thermal deactivation. This study may provide new and complementary details regarding the design and development of enzymes in industrial applications.
Jitendra Sharma
S M S Medical College, India
Title: Clinical, radiological and microbiological profile of pulmonary aspergillosis in treated cases of pulmonary tuberculosis
Biography:
Jitendra Kumar Sharma is a senior resident in Sawai Man Singh Medical College. He has completed his MBBS. He is also State Coordinator of Jaipur Associations of Resident Doctors.
Abstract:
Biography:
Abstract:
Yohannes Negesse
Centre Hospitalier Universitaire de la Guadeloupe, France
Title: The importance of defining hanseniasis according its pathophysiological nature as a noncurable chronic autoimmune and autoinflammatory disease. Bridging the gap between individual and collective medicines based on the principle of complementarity of deep contradictory truths
Biography:
Yohannes Negesse is a Pathologist trained in France and USA. He has worked for more than 20 years in Ethiopia in different institutions. He is presently working in the Centre Hospitalier Universitaire de la Guadeloupe. France. He has published more than 20 papers in the field of infectious diseases pathology.